A Roman naturalist named Pliny the Elder discovered the healing power of black walnuts in the first century . Herbalist Nicholas Culpeper prescribed walnut to draw poisonous venom from snake and spider bites in the 17th century. Native Americans used the bark, leaves, husk and nuts from black walnut trees medicinally, particularly as a mosquito repellant and to treat skin conditions and psychological disorders. They were also the first to use hulls as a natural laxative and for eliminating parasites in the intestine, which is the most commonly implemented today.
Oral exemestane 25 mg/day for 2–3 years of adjuvant therapy was generally more effective than 5 years of continuous adjuvant tamoxifen in the treatment of postmenopausal women with early-stage estrogen receptor-positive/unknown receptor status breast in a large well-designed [ citation needed ] trial. Preliminary data from the open-label TEAM trial comparing exemestane with tamoxifen indicated in 2009 that exemestane 25 mg/day is also effective in the primary adjuvant treatment of early-stage breast cancer in postmenopausal women.