Testosterone therapy risks

Other significant adverse effects of testosterone supplementation include acceleration of pre-existing prostate cancer growth in individuals who have undergone androgen deprivation; increased hematocrit , which can require venipuncture in order to treat; and, exacerbation of sleep apnea . [20] Adverse effects may also include minor side-effects such as acne and oily skin, as well as, significant hair loss and/or thinning of the hair, which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia , such as finasteride . [21] Exogenous testosterone may also cause suppression of spermatogenesis , leading to, in some cases, infertility. [22] It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor PSA and hematocrit levels closely during therapy. [23]

Diabetes mellitus is a disease in which a person's blood sugar (blood glucose) is either too high (hyperglycemia) or too low (hypoglycemia) due to problems with insulin regulation in the body. There are two main types of diabetes mellitus, type 1 and type 2. Type 1 diabetes usually occurs during childhood, while type 2 diabetes usually occurs during adulthood, however, rates of both types of diabetes in children, adolescents, and teens is increasing.

More men than women have diabetes in the US, and the disease can affect men differently than women.

Warning symptoms of diabetes that men have and women do not include:

  • Low testosterone (low-T)
  • Sexual problems
  • Impotence (erectile dysfunction)
  • Decreased interest in sex
  • Retrograde ejaculation

Type 1 and type 2 diabetes symptoms and signs that are the same in men and women include:
  • Skin infections
  • Numbness or tingling in the feet or hands
  • Nausea
  • Excessive thirst or hunger
  • Fatigue
  • Irritability
  • Blurred vision
  • Weight gain
  • Weight loss
  • Urinary tract infections (URI)
  • Kidney problems

Treatment for type 1 diabetes is insulin, and treatment for type 2 diabetes are lifestyle changes like eating a healthy diet, getting exercise daily, and if necessary, diabetes medications.


NIH; National Institute of Diabetes and Digestive and Kidney Diseases. "Preventing Type 2 Diabetes. Updated: Nov 2017.

NIH; National Institute of Diabetes and Digestive and Kidney Diseases. "Symptoms and Causes of Diabetes." Updated: Nov 2017.

Testosterone therapy risks

testosterone therapy risks


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