Testosterone effects on the brain

Physicians and those in the mental health fields suddenly noticed that a substantial percentage of depressed men were low T and giving them testosterone helped very often.  The subject of Testosterone and Depression is so important that I did a page on it and documented the many kind of depression and mood conditions that HRT can help with.  In my opinion, if a man is struggling with depression, one of the first numbers that should be pulled is testosterone.

Testosterone is a hormone that plays a key role in carbohydrate, fat and protein metabolism. It has been known for some time that testosterone has a major influence on body fat composition and muscle mass in the male. Testosterone deficiency is associated with an increased fat mass (in particular central adiposity), reduced insulin sensitivity, impaired glucose tolerance, elevated triglycerides and cholesterol and low HDL-cholesterol. All these factors are found in the metabolic syndrome (MetS) and type 2 diabetes, contributing to cardiovascular risk. Clinical trials demonstrate that testosterone replacement therapy improves the insulin resistance found in these conditions as well as glycaemic control and also reduces body fat mass, in particular truncal adiposity, cholesterol and triglycerides. The mechanisms by which testosterone acts on pathways to control metabolism are not fully clear. There is, however, an increasing body of evidence from animal, cell and clinical studies that testosterone at the molecular level controls the expression of important regulatory proteins involved in glycolysis, glycogen synthesis and lipid and cholesterol metabolism. The effects of testosterone differ in the major tissues involved in insulin action, which include liver, muscle and fat, suggesting a complex regulatory influence on metabolism. The cumulative effects of testosterone on these biochemical pathways would account for the overall benefit on insulin sensitivity observed in clinical trials. This review discusses the current knowledge of the metabolic actions of testosterone and how testosterone deficiency contributes to the clinical disease states of obesity, MetS and type 2 diabetes and the role of testosterone replacement.

Side-effects are not expected because testosterone therapy aims to bring a man’s testosterone levels back to normal. However, testosterone therapy can increase the growth of the prostate gland which can make the symptoms of benign prostate enlargement (such as needing to urinate more often) worse. In the case of prostate cancer, testosterone therapy is not used because of concerns that it can make the tumour grow. Too high a dose of testosterone can lead to acne, weight gain, gynaecomastia (breast development), male-pattern hair loss and changes in mood. Any side-effects should be managed by a doctor and the testosterone dose lowered.

Limitations of these studies are that they are done on limited subjects and also that we’re now in 2014. More research has been done since then and the use of Human Chorionic Gonadotropin (HCG) is common now amongst steroid users. HCG will mimic luteinizing hormone (LH) and stimulate the testes to maintain intra-testicular testosterone (ITT) even when shutdown through the use of anabolic steroids. This will help increase sperm count significantly and we’ll go as far as to suggest using it if you’re trying for a baby at no more than 1,000 ius every four days.

Testosterone effects on the brain

testosterone effects on the brain

Limitations of these studies are that they are done on limited subjects and also that we’re now in 2014. More research has been done since then and the use of Human Chorionic Gonadotropin (HCG) is common now amongst steroid users. HCG will mimic luteinizing hormone (LH) and stimulate the testes to maintain intra-testicular testosterone (ITT) even when shutdown through the use of anabolic steroids. This will help increase sperm count significantly and we’ll go as far as to suggest using it if you’re trying for a baby at no more than 1,000 ius every four days.

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