A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.
Most of you on here that are posting about a womens insecurites – you’re obviously not reading or understanding what we are writing… I am 100% comfortable with my body and sexual needs. i love trying new things and really getting into sex… my partner and i were having sex atleast twice a day for the first year… then alteast 5 days a week for the following 2 years… now going on to our 4th year.. he’s really starting to make me question our relationship… as mentioned in the rest of the posts – we now only have sex mayyyybe once a week.. my sex drive has gone through the roof but my man is either too tired, too lazy to return “the favour” or litterally just laughs and says “maybe i should take more testosterone” jokingly…. however… i find it funny that he has the time and effort to scope the internet for porn but ALSO now youtube just to scope sexy chicks!