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Possible risk factors for leukopenia/neutropenia include pre-existing low white blood cell count (WBC)/absolute neutrophil count (ANC) and history of drug-induced leukopenia/neutropenia. In patients with a history of a clinically significant low WBC/ANC or a drug-induced leukopenia/neutropenia, perform a complete blood count (CBC) frequently during the first few months of therapy. In such patients, consider discontinuation of Invega Sustenna ® at the first sign of a clinically significant decline in WBC in the absence of other causative factors.
I’m disturbed by unanimous condemnation of prefrontal lobotomy. I don’t think it’s fair. I’d guess that nearly everyone who has written in has never dealt with wildly psychotic manic or delirious persons. In the days that psychosurgery was performed there were no effective alternative treatments, no means of controlling dangerous injurious behaviors except restraints and torture such as immersion and these worked only temporarily and required prolonged hospital confinement. Many lobotomized persons were able to be discharged home. “Desperate Cures” is an apt description and Moniz and Freeman were not Joseph Mengeles. Freeman was certainly guilty of self aggrandizement and performing his procedures sloppily and too widely. The American media helped to popularize a procedure that reduced most to a state of docility and inertia. Lobotomies may have had limited efficacy at one time but are now simply outmoded. Medicine marches on.