It is clear that the effects of TRT appear at different rates (Figure). Although the full benefits of TRT may not appear until after the first year of treatment, improvements in libido, erectile function, mood, depression and quality of life typically occur earlier. This is also true for changes in PSA and haematocrit. Finally, the studies selected for the present analysis provided testosterone treatment that delivered adequate doses and delivery of testosterone. The use of sub-optimal therapeutic regimens or the inappropriate use of TRT in eugonadal men or those with biochemical hypogonadism in the absence of clinical symptoms are likely to show different time courses of effects.
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