It generally only takes a low dose of T3 to treat hypothyroidism. This will not necessarily promote enhanced fat loss, but it should return the metabolism back to proper working order. However, many performance enhancing athletes enjoy using triiodothyronine to in fact enhance direct fat loss. The use of Triiodothyronine alongside a calorie restricted diet will promote significant and accelerated fat loss. While effective, generally this type of use cannot be recommended without the use of anabolic steroids. Due to the necessarily higher doses needed to promote enhanced fat loss and due to the depletion of ATP (Adenosine triphosphate), this can promote lean tissue loss. The body will take whatever it needs from wherever it can get it to meet its energy demands. For this reason, an anabolic protectant is normally advised when supplementing with T3 for this purpose.